Can You Take Tylenol And Ibuprofen Together For Pain Relief? 
Written By Kobi Nathan, Pharm.D., M.Ed., CDP, BCGP, AGSF
Sleep Disorders
March 22, 2023

Can acetaminophen (Tylenol) and ibuprofen (Advil) be taken together?

Short answer: Yes, you can take ibuprofen and acetaminophen together (not spaced apart). They work synergistically to reduce pain and inflammation quickly and effectively.

Is taking these two drugs together for increased pain relief safe, though? Let’s investigate each drug’s specifics to find out.

Read on for the detailed answer:

Ibuprofen and Tylenol Overview

Many people use over-the-counter (OTC) drugs like Tylenol (acetaminophen) or ibuprofen when in discomfort. Both are well-liked solutions for treating minor aches, discomfort, and fever.


Acetaminophen, referred to as Tylenol (paracetamol in countries outside the U.S.), is used to treat pain and lower fever.

It works by affecting the brain’s heat-regulating center and the body’s pain signals.

The precise mechanism of how acetaminophen works is still unknown.

It is theorized to stop the synthesis of prostaglandins, molecules that cause inflammation and pain in the body.

Ibuprofen Action

Ibuprofen is a nonsteroidal anti-inflammatory medication (NSAID) that works by preventing the production of prostaglandin-producing enzymes.

This process results in a decrease in fever, discomfort, and inflammation.

NSAIDs work much better at decreasing inflammation in the body than acetaminophen.

Ibuprofen is frequently used to treat various arthritic conditions, headaches, menstrual cramps, and toothaches.

If you want to learn more about NSAIDs from my perspective as a clinician and educator, please read my detailed article here.


You can take acetaminophen and ibuprofen at the same time for increased pain relief

Taking Tylenol and ibuprofen together can provide more effective pain relief than taking each drug alone. They each operate through different pathways, so combining them may synergistically improve pain management.

Let’s define synergism: It is how two or more substances or other agents work together or with each other to make a combined effect greater than the sum of their individual effects.

I describe this concept in terms of acetaminophen and ibuprofen below:

Lower adverse effects of ibuprofen and acetaminophen

Compared to taking one treatment at a greater dose, administering both medications at lesser doses may potentially lessen the risk of negative drug effects. When you take acetaminophen in the recommended dosage, it is generally regarded as safe.

However, using too much can harm the liver. It is VERY easy to overdose on acetaminophen.

When taken in excessive doses, acetaminophen can cause irreversible liver damage. In medical speak, we call it fulminant hepatotoxicity.

For example, I ALWAYS ask my patients if they take any sleep aids for their insomnia (my detailed article on this topic, including its management).

Many OTC medications contain acetaminophen or ibuprofen. Common examples are Tylenol PM, Advil PM, Nyquil or Zzzquil (my article on the differences between the two products), etc.

Quick aside here, it is always a good idea to understand the concept of anticholinergic burden in older adults, especially if cognitive impairment or dementia is a concern. The hyperlinked words will bring you to my articles about these topics.

The evidence is clear – there is a link between dementia and cumulative use of OTC and prescription anticholinergic medications. I discuss this study with my pharmacy students and my medical colleagues when I am giving Medicine Grand Rounds talks.

OK, back to ibuprofen – In contrast, greater doses of ibuprofen may result in stomach irritability, ulcers, or kidney problems.

Lower dosages and fewer adverse effects may be possible with the combination of the two medications.

Lessened Dosage Needs of ibuprofen or acetaminophen

Tylenol and ibuprofen working together may reduce the need for greater doses of each drug, lowering the risk of unwanted medication effects and complications.

This graphic taken from a clinical study published in the Journal of the American Dental Association shows the powerful pain-relieving effect of combining ibuprofen and acetaminophen:




As you can see from the image above, pain relief is dose-dependent and synergistic.

This is the study I cite when I am teaching the dental residents at my local dental school every spring when I lecture on polypharmacy and medication safety in older adults. I have also written about these topics here if you want to read about them.

Back to this combination regimen – To put this into a personal context, I get bad migraines, and the only dose of ibuprofen that would seem to work to reduce my pain was 800 mg. Decent pain relief for me would begin about 45 minutes after taking the ibuprofen.

Taking 1000 mg of acetaminophen alone would not even come close to touching the pain for me.

However, I was concerned about taking such as high dose of ibuprofen. When I came across the above article, I decided to try it out for myself.

The next time I started getting a headache, I took 400 mg of ibuprofen and 1000mg of acetaminophen together (not spaced apart) and timed my pain relief.

The pain relief started occurring even faster than when I took the 800 mg dose of ibuprofen. 25 minutes after I took the combination dose, I was COMPLETELY pain-free! 

Since then, this is the dosing regimen I have used every time I feel a migraine starting.

Please keep in mind that this regimen works for me and may not work for you. You may have to experiment with different dosing combinations to get your ideal pain relief.

I would be remiss not to mention this – Yes, I am a pharmacist, but I am NOT your pharmacist. Please do not take my information in this article as medical advice. ALWAYS consult your medical provider before starting or changing your pain-relieving medications.

Why do I say this? Because there are SO MANY variables and factors to consider – do you have or take:

  • Kidney Disease.
  • Liver Disease.
  • Heart Disease.
  • Heart Failure.
  • High Blood Pressure.
  • Aspirin as secondary heart attack prevention.
  • Anticoagulants for atrial fibrillation such as apixaban or rivaroxaban.
  • Cilostazol for peripheral artery disease.
  • Allergies to acetaminophen or NSAIDs (some could be life-threatening).

And SO MANY MORE reasons, too numerous to name here.

A good, ethical educator and clinician will consider all of these things when advising on an online forum. The information presented here is meant to educate.

I hope you will take this information to your doctor and have a meaningful, empowered, and goal-directed conversation with them. The relationship between you and your doctor is sacrosanct. I never want to insert myself inappropriately into this relationship.

Okay, back to our topic…

Time and dosage must be right

When taking Tylenol and ibuprofen at the same time, it is essential to follow the recommended dosing and timing instructions.

The combination dose I recommend to my patients is 400 mg ibuprofen and 1000 mg (or 975 mg if you have the 325 mg caplets: 325 mg x 3=975 mg) of acetaminophen taken together, spaced 8 hours apart, around the clock until symptom resolution. Depending on the situation, a day or two of this dosing schedule will suffice for most of my patients.

Again, I can do this with my patients because I have access to their complete medical history, medications, and labs and an established provider-patient relationship with them.

As I mentioned above, your situation may be different, and taking these medications could harm you without medical oversight from your healthcare provider. ALWAYS listen to them!

Always read the directions on the container, though, and heed any advice given to you by your healthcare provider.

Potentially Interacting Drugs

Before combining the two, ensure you are not taking any other medications that might interfere with either Tylenol or ibuprofen.

Aspirin or naproxen, for instance, should not be taken with ibuprofen because doing so may raise the chance of side effects, especially life-threatening bleeding!

Moreover, Tylenol may interact with several drugs, perhaps causing liver damage or other problems.

Always speak to your doctor or pharmacist if you have questions regarding potential interactions.

Consultation with a Medical Professional

Chronic or Increasing Pain

It’s important to consult a doctor if your pain does not go away or worsens after taking Tylenol and ibuprofen together. This can point to a more serious underlying problem that needs more analysis and care.

Signs of Allergic Response

Tylenol and ibuprofen can potentially cause allergic reactions in certain people. Hives, breathing problems, and swelling of the face, lips, or throat can all be symptoms. Get emergency medical help if you encounter any of these symptoms.


In conclusion, some people may have increased pain relief when taking Tylenol and ibuprofen combined, as well as the added advantages of fewer side effects and lower dosage requirements.

But it’s crucial to follow the right timing and dosage instructions, be mindful of drug interactions, and track how your body responds to the medication.

If you have any questions about mixing these drugs or if your pain persists or worsens, always seek medical advice.


Q1: Can I combine Tylenol and ibuprofen to relieve pain?

A: If the right dosage and timing recommendations are followed, taking Tylenol and ibuprofen together can give some people better pain relief.

Q2: How can Tylenol and ibuprofen combine to relieve pain?

A: Tylenol and ibuprofen have different pain-relieving effects; therefore, taking them together may result in better pain management than taking either drug separately.

Q3: What possible side effects and risks could there be if you combine Tylenol and ibuprofen?

A: Possible side effects and hazards include nausea, vomiting, sleepiness, and, in rare instances, liver or kidney damage.

Q4: When should I visit a medical expert when using Tylenol and ibuprofen together?

A: If your pain persists or worsens, if you exhibit symptoms of an allergic reaction, or if you have questions about mixing these medications, talk to your doctor.

Q5: When should I take Tylenol and ibuprofen together, and what amounts should I use?

A typical recommendation for adults is to take 400 mg of ibuprofen and 975 -1000 mg of Tylenol every 8 hours. For more specific advice, ask your doctor or pharmacist.

Additional Tips for Combining Tylenol and Ibuprofen Safely

Maintain a Medicine Log

Maintaining a medication record will help you keep track of your dosages and timing when taking numerous drugs, including Tylenol and ibuprofen. Doing this can prevent mistakenly taking more medication than prescribed or being too close together.

Keep hydrated

When taking drugs like Tylenol and ibuprofen, you should drink plenty of water to reduce adverse effects, especially gastrointestinal ones. In addition to supporting kidney function, adequate hydration lowers the risk of kidney problems caused by NSAIDs like ibuprofen.

Skip the alcohol

When combining Tylenol and ibuprofen, it’s important to avoid alcohol because it might worsen gastrointestinal side effects from ibuprofen and raise the risk of liver damage from acetaminophen.

Observe any side effects

When taking Tylenol and ibuprofen, keep an eye out for any indications of side effects or difficulties. Stop using it immediately and seek medical advice if you notice any alarming symptoms.

Alternatives to Tylenol and Ibuprofen Together

If you’re hesitant to take Tylenol and ibuprofen together for pain relief or worry about possible side effects, talk to your doctor about other options. They might suggest further pain management techniques like:

  • Topical painkillers: Gels, creams, or patches that reduce regional pain without oral drugs.
  • Prescription drugs: Depending on your unique pain management requirements, your doctor may occasionally prescribe a different drug.
  • Physical therapy or massage: These treatments could help with musculoskeletal pain by reducing discomfort and enhancing mobility.
  • Heat or cold therapy: Can help with various types of pain, including joint inflammation and muscle pains.
  • Lifestyle changes: In certain circumstances, adjusting your daily routine, such as exercising, changing your food, or learning to manage your stress, can help you feel better overall and reduce your pain.

Never forget to speak with a medical expert if you have questions about your existing pain reduction strategy or before applying new pain management techniques.

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