Baclofen vs Tizanidine: Which is Stronger for Spasticity?
Written By Kobi Nathan, Pharm.D., M.Ed., CDP, BCGP, AGSF
Sleep Disorders
April 14, 2023

Spasticity is a common symptom in various neurological conditions, such as multiple sclerosis, spinal cord injury, and stroke.

It is characterized by involuntary muscle contractions, stiffness, muscle weakness, and spasms that can cause pain, functional limitations, and reduced quality of life.

Effective spasticity management and pain relief improve patient outcomes and maintain daily living activities.


Overview of baclofen and tizanidine as muscle relaxants

Baclofen and tizanidine are two commonly prescribed muscle relaxants used to manage spasticity.

Both medications work to reduce muscle tone, but they have different mechanisms of action and clinical applications.

This article provides a brief overview of baclofen and tizanidine, highlighting their similarities and differences to help guide the selection of the right muscle relaxant for spasticity management.

Baclofen: A Brief Overview

Mechanism of action

Baclofen is a gamma-aminobutyric acid (GABA) agonist that works by inhibiting the release of excitatory neurotransmitters in the central nervous system (CNS).

This action leads to reduced muscle tone and spasticity.

Indications and clinical applications


Baclofen is primarily used to treat spasticity in patients resulting from spinal cord injuries, multiple sclerosis, and other neurological conditions.

It is available in oral and intrathecal (directly into the spinal fluid) forms. It is sold under the brand name Lioresal.

Intrathecal baclofen is typically reserved for patients with severe spasticity who do not respond adequately to oral therapy.

Dosage and administration

The oral baclofen dosage varies based on the severity of spasticity and individual response to treatment.

Typically, treatment starts with a low dose, which is gradually increased until the desired therapeutic effect is achieved.

The usual adult starting dose of baclofen tablets is 5 mg three times daily, with a maximum daily dose of 80 mg. 

As with any medication, you should not take expired baclofen.

Intrathecal baclofen is administered through an implanted pump, with dosages determined by a healthcare professional based on individual patient needs.


Tizanidine: A Brief Overview

Mechanism of action

Tizanidine is an alpha-2 adrenergic agonist that works by inhibiting the release of excitatory neurotransmitters in the spinal cord, decreasing muscle tone and spasticity. It is sold under the brand name Zanaflex.

Unlike baclofen, tizanidine does not directly affect GABA receptors.

Indications and clinical applications

Tizanidine is used to manage spasticity caused by multiple sclerosis, spinal cord injury, and other neurological disorders. Tizanidine is available in oral form, with no intrathecal option. 

Tizanidine is primarily used as a short-acting muscle relaxant for acute episodes of spasticity or in addition to other treatments, such as physical therapy.

Dosage and administration

The tizanidine dosage is individualized, with treatment typically starting at 2 mg and gradually increasing based on your response and tolerance.

The maximum daily dose of tizanidine is 36 mg. Due to its short half-life, tizanidine is usually taken multiple times daily to maintain its therapeutic effect.


Comparing the efficacy of tizanidine versus baclofen

Treatment outcomes in various neurological conditions

1. Multiple sclerosis

Both tizanidine and baclofen have shown efficacy in reducing muscle spasticity in patients with multiple sclerosis.

A study comparing the two medications found that baclofen and tizanidine provided similar improvements in spasticity reduction, but tizanidine had a faster onset of action and was better tolerated by patients.

2. Spinal cord injury

In patients with spinal cord injuries, baclofen and tizanidine have demonstrated effectiveness in managing spasticity.

One study comparing the two medications found no significant differences in spasticity reduction, but patients receiving tizanidine reported fewer side effects and better overall satisfaction.

3. Cerebral palsy

Limited data are available on the efficacy of tizanidine in cerebral palsy patients, but baclofen has been widely studied and is considered effective for managing spasticity in this population. Intrathecal baclofen has been particularly beneficial in patients with severe spasticity who do not respond well to oral medications.

4. Stroke

Baclofen and tizanidine have both been used to manage spasticity in stroke patients.

Studies comparing the two medications are limited, but they generally suggest that both drugs effectively reduce spasticity and improve functional outcomes.

Comparative studies and meta-analyses

A meta-analysis comparing the efficacy and safety of baclofen and tizanidine in patients with spasticity found no significant differences in overall spasticity reduction between the two medications. However, tizanidine was associated with fewer side effects and greater patient satisfaction.

Factors influencing treatment efficacy

Several factors, including individual patient characteristics, the severity of spasticity, and specific neurological condition can influence treatment efficacy for baclofen and tizanidine.

In addition, the dosage and administration route can impact treatment outcomes.

For example, intrathecal baclofen may be more effective than oral baclofen in patients with severe spasticity who do not respond adequately to oral medications.

Safety and Side Effects

Common side effects of baclofen and tizanidine

Both baclofen and tizanidine can cause a range of side effects, some of which are similar.

Common adverse effects of both medications include drowsiness, dizziness, and weakness. However, each medication also has its own unique set of side effects:

  • Baclofen: Nausea, constipation, and urinary retention are some negative effects more commonly associated with baclofen.
  • Tizanidine: Dry mouth, hypotension (low blood pressure), and liver function abnormalities are more frequently reported side effects of tizanidine.

Serious adverse effects and contraindications

Although generally considered safe when used as directed, baclofen and tizanidine may cause serious adverse effects in some cases:


Abrupt discontinuation of baclofen, particularly at high doses, can lead to withdrawal symptoms such as hallucinations, seizures, and high fever.

Baclofen should be tapered off gradually under a doctor’s supervision to minimize the risk of withdrawal.


Tizanidine has been associated with liver injury, including acute liver failure in rare cases.

If your doctor has prescribed this medication for you, be sure to ask them about having your liver function checked and monitored regularly during treatment.

If liver injury is suspected, tizanidine should be discontinued.

Contraindications for baclofen include hypersensitivity to the drug and severe renal impairment.

Tizanidine is contraindicated in patients with hypersensitivity to the drug and those with severe liver impairment.

Drug interactions and precautions

Both baclofen and tizanidine have the potential to interact with other medications:


Use with caution in combination with other central nervous system (CNS) depressants, such as alcohol, benzodiazepines, or opioids, as this may increase the risk of sedation and respiratory depression.

Baclofen may also interact with medications that affect kidney function, such as nonsteroidal anti-inflammatory drugs (NSAIDs).

An important point here: I am not saying that baclofen and NSAIDs are contraindicated.

In my clinical practice, I recommend using baclofen and ibuprofen for effective spasticity and pain management in CERTAIN patients.

And only after carefully assessing my patients’ overall clinical status, including kidney function, bleeding risk, and blood pressure.

I do not recommend using NSAIDs in any of my patients who are older, frail, or have medical conditions that put them at risk for harm.

To understand why I do this, I highly recommend you read my article on NSAIDs linked in the paragraph above.


Tizanidine has a very clinically significant drug interaction with certain medications.

Some examples are fluvoxamine or ciprofloxacin. These drugs can significantly increase tizanidine blood levels, increasing the risk of adverse effects.

Tizanidine should also be used with caution in combination with other CNS depressants, as this may increase the risk of sedation and respiratory depression.

You should inform your doctor of all medications, including over-the-counter medications and dietary supplements you are taking to minimize the risk of drug interactions.

Polypharmacy is the 5th leading cause of death among older adults in the United States!

To understand why, please read my article on this topic here.


Patient Selection and Personalized Treatment Approaches

Factors to consider when choosing between baclofen and tizanidine

When selecting the most appropriate muscle relaxant for spasticity management, healthcare providers should consider several factors:

Severity of spasticity

The severity of spasticity can influence the choice of medication. For example, intrathecal baclofen may be more appropriate for patients with severe spasticity who do not respond adequately to oral medications.

Comorbidities (presence of two or more medical conditions)

Patients with certain comorbidities may benefit from one medication over the other.

For example, tizanidine might be better for patients with kidney issues, while baclofen might be more suitable for patients who cannot tolerate hypotension (low blood pressure).


As discussed earlier, baclofen is contraindicated in patients with severe renal impairment, while tizanidine is contraindicated in those with severe liver impairment.

Your doctor should consider your medical history and potential contraindications when selecting the right muscle relaxant for you.

Patient preferences

Your preferences should also be considered, as tolerability and satisfaction with the medication can impact treatment adherence and overall outcomes.

For example, if you prefer a faster onset of action and better medication tolerability, you may prefer tizanidine over baclofen.

The role of combination therapy

In some cases, healthcare providers may recommend a combination of muscle relaxants to optimize spasticity management.

For example, combining baclofen with tizanidine could potentially provide additive or synergistic effects, improving spasticity control while minimizing the side effects associated with higher doses of either medication alone.

An excellent example of synergy is explained in my article about combining acetaminophen (Tylenol) with ibuprofen. 

In my clinical practice, I recommend combination therapy with tizanidine and baclofen very often for my patients, especially when they are still experiencing significant spasticity with baclofen therapy alone.

Strategies for optimizing treatment outcomes

To maximize treatment outcomes, healthcare providers should take a personalized approach to spasticity management, considering factors such as the patient’s specific neurological condition, the severity of spasticity, and any comorbidities or contraindications.

In addition, patients should be closely monitored for side effects and medication adherence, and dosage adjustments should be made as necessary to achieve optimal therapeutic effects while minimizing side effects.


Recent Advances and Future Directions

Novel formulations and delivery methods

Researchers are continuously exploring novel formulations and delivery methods for baclofen and tizanidine to improve their efficacy, tolerability, and ease of administration.

For example, extended-release formulations of these medications are being investigated to provide more consistent and sustained spasticity control while reducing dosing frequency.

Additionally, new delivery methods, such as intrathecal baclofen pumps, have already shown promising results in providing targeted spasticity relief for patients with severe spasticity.

Ongoing research on baclofen and tizanidine

Ongoing research on baclofen and tizanidine aims to understand their mechanisms of action further, optimize their use in clinical practice, and uncover potential new applications.

For instance, recent studies have investigated baclofen’s potential neuroprotective effects in animal models of neurodegenerative diseases, such as Parkinson’s disease.

Similarly, tizanidine has been studied for its potential role in managing pain and inflammation in animal models of neuropathic pain.

Potential new indications for these muscle relaxants

As our understanding of baclofen and tizanidine’s pharmacology and clinical applications continues to grow, new indications for these medications may be identified.

For example, baclofen is currently being investigated for its potential use in treating alcohol use disorder, as it has shown promise in reducing alcohol craving and consumption in preliminary clinical trials.

Similarly, tizanidine has been explored for its potential role in managing chronic pain conditions such as fibromyalgia.



This article compared baclofen and tizanidine, two commonly prescribed muscle relaxants for managing spasticity associated with various neurological conditions.

Both medications have distinct mechanisms of action, indications, and dosing regimens.

While both drugs effectively manage spasticity, their efficacy may vary depending on the specific neurological condition and the individual patient.

Comparative studies have shown mixed results regarding the superiority of one medication over the other, highlighting the importance of considering factors such as the severity of spasticity, comorbidities, contraindications, and patient preferences when selecting the most appropriate treatment.

Both medications have potential side effects and drug interactions, making it essential for patients to be closely monitored during treatment.

The importance of individualized treatment approaches for spasticity management

Ultimately, the choice between baclofen and tizanidine for spasticity management should be guided by a personalized treatment approach considering the patient’s specific needs and circumstances.

This may involve considering the severity of spasticity, the presence of comorbidities, potential contraindications, and patient preferences.

Combination therapy and alternative formulations or delivery methods may also be explored to optimize treatment outcomes.

As research on baclofen and tizanidine continues to advance, novel formulations, delivery methods, and potential new indications may be identified, further expanding our understanding and ability to manage spasticity in patients with neurological conditions effectively.

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